Projects
Projects in the Cardiac Arrest Network
The COCA trial is a randomized, double-blind, placebo-controlled trial evaluating calcium chloride (CaCl) as an intra-arrest intervention for patients with out-of-hospital cardiac arrest. The primary aim of the project is to test whether CaCl – in addition to standard treatment – can improve the proportion of patients regaining spontaneous circulation at hospital arrival.
The study is a randomized, controlled, simulation study comparing two different strategies for cardiopulmonary resuscitation performed by laypersons in a setting of multiple rescuers present. A total of 160 laypersons will be included.
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This PhD project aims to improve the efficacy and safety of electrical direct current cardioversion of atrial fibrillation. The studies are designed as randomized clinical trials to provide data on the clinical best-practise for cardioverting atrial fibrillation. The studies aim to investigate cardioversion waveform, energy levels and electrode positions for cardioversion.
The studies are planned to actively enroll patients between 2016 – 2020.
In this observational cohort study, we aimed to compare patient characteristics, cardiac arrest event characteristics, and outcomes for in-hospital and out-of-hospital cardiac arrest patients in Denmark. The primary endpoint was 30-day survival. Secondary outcomes were return of spontaneous circulation and one-year survival.
This mixed-methods simulation study aims to investigate if structural and functional components of commercial AEDs can be improved with more user-friendly designs and instructions, and whether this can shorten time to defibrillation by laypersons.
Every year around 2,500 people suffers a cardiac arrest in Danish hospitals and less than one out of three will survive. The aim of this project is to optimize the use of automated external defibrillators during in-hospital cardiac arrest. The project will contribute with important knowledge about why automated external defibrillators are not always used during in-hospital cardiac arrest and which factors we can improve to save more lives. If we can improve the chance of surviving an in-hospital cardiac arrest by 1 percentages point , we can save 25 more lives every year.
Socioeconomic factors may influence outcomes through multiple mechanisms including difference in co-morbidities and differential treatments including less aggressive care.
However, little is known about the impact of socioeconomic factors in patients with in-hospital cardiac arrest both in Denmark and internationally. We wish to assess the relationship between socioeconomic factors and treatments and outcomes for patients with in-hospital cardiac arrest in Denmark. Identifying such relationships will facilitate interventions to improve equality in treatment and outcomes.
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest (VAM-IHCA) - A Randomized, Double-Blind, Placebo-Controlled Trial.
This study aims to improve patient survival and neurological outcome of cardiac arrest. The VAM-IHCA trial is a national Danish study that has the potential to change international guidelines for treatment of cardiac arrest.
Projects in the CONSIDER Sepsis Network
AQUA24 - Description of current fluid administration practice in adult emergency department patients with suspected infection; a multicenter, prospective, observational study
The project aims to describe current 24 hour fluid administration practices in ED patients with suspected infection and assesses the association between patient and disease characteristics and variations in amount of fluid administration.
The project aims to describe the difference in fluid treatment in patients with suspected infection brought in by ambulance and patients arriving on their own.
The study will look at total and intravenous fluid amount in 6 hours and 24 hours after the patient is admitted to the Emergency Department.
This study is a multicenter, prospective, observational study.
This study will bring knowledge about the effect on prehospital transportation on fluid treatment in patients with suspected infection.
Projects in the Design-EM Network
My projects aims at investigating how healthcare professionals use an information system (IS) to support patient treatment in a shift work context. Theoretically, use is motivated by a number of factors related to the individual user’s domain such as usefulness to the individual user’s work or ease of use. In a setting in which close collaboration not only within a single work shift, but also across is a prerequisite for the quality of patient care/outcome, the use of IS may be motivated by other factors than usefulness and ease of use.
The overall purpose of the project is to characterize the current organisation of emergency departments in Denmark and to investigate the relation between organisational design of emergency departments and quality of care, health outcomes and costs.
Treatment of elderly patients in own home – a cross-sectorial alternative to emergency admission
The purpose of this research project is to avoid cases with unnecessary emergency admissions of elderly, medical patients to reduce the risk of infections, delirium and physical and psychical loss of function at a vulnerable patient group.
Projects in the International Network
TAME Cardiac Arrest is a phase III, multi-centre, randomised, parallel-group, controlled trial to determine whether targeted therapeutic mild hypercapnia (TTMH) improves neurological outcome at 6 months compared to standard care (targeted normocapnia (TN)) in resuscitated cardiac arrest patients who are admitted to the intensive care unit.
The project aims to determine whether external administration of ubiquinol (reduced coenzyme Q10) increases physiological ubiquinol levels and decreases markers of neurological injury.
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Projects in Patient Safety Network
The overall aim is this project is to improve the performance of PEWS and its acceptability among healthcare professionals. Three studies including a scoping review, a Delphi study and a prospective, cluster-randomized cross-over project will be conducted. The project will contribute to the existing knowledge of PEWS and nurses’ clinical judgment in relation to clinical deterioration of children.
The project investigates ambulatory care sensitive conditions (ACSCs) among patients with multimorbidity. The project uncovers patient-related and organisational characteristics of admissions to hospital emergency departments. The aim is to develop and test risk assessment tool for use in primary care in order to prevent certain acute admissions effectively.
Other Projects
Diagnostic Change
Is patient outcome associated with change of ICD10 diagnose from the ED to hospital discharge?
This study aims to investigate the association between diagnostic concordance of dyspneic ED patients and the length of inpatient-unit stay, readmission, and mortality.
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Chief Complaints
Predicting mortality and readmission based on chief complaint in emergency department patients - A retrospective cohort study from a Danish university hospital using Danish Emergency Process Triage (DEPT)
Most research characterize and risk stratify ED patients according to discharge diagnoses; however, ED patients present with symptoms/complaints and not diagnoses, and many are never diagnosed. Characterization and risk stratification of patients in the EDs based on the presenting chief complaint could help optimize ED workflow and reduce risk.
The primary aim of the PhD is to describe and improve the management of acute pain in patients with a chronic use of opioids.
Three studies are planned in this PhD to estimate and describe the proportion of chronic opioid users in Denmark. Furthermore to evaluate risk factors for insufficient pain treatment. Data are based on several Danish registers and a randomized, controlled, double-blinded, superiority trial conducted in two of the largest EDs in Denmark.
SHINE-Trauma
Shock-induced Endotheliopathy in Trauma
SHINE-TRAUMA is an investigator-initiated, multicenter, randomized, placebo-controlled, double-blind, phase 2b-trial. The aim of this trial is to investigate whether continuos infusion of iloprost for 72-hours is safe and significantly increase the number of ICU free days, within 28 days from admission compared to placebo in trauma patients with haemorrhagic shock and SHINE, across the country. The trial is initiated by Rigshospitalet.
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The overall purpose of the project is to describe and characterize the evolution of trauma epidemiology and mechanisms over the past 20 years in a representative region of Denmark.
The focus will be concerned trauma types, severity, epidemiological parameters, uptake area and vital parameters upon arrival at the Aarhus University Hospital Trauma Center.